While explaining homeopathy on the basis of scientific perspective of MIT, I have been proposing the idea that it is the ‘functional groups’ of drug molecules and pathogenic molecules that interact with biological molecules, and as such, any drug having similar functional groups or moieties can act as similimum in their potentized form. Now we have a a wonderful meta-analysis of research works that validates this idea by scientific methods.
You can read this meta-analysis ‘A Review of Use of Enantiomers in Homeopathy’ by R. M. Kuzeff, National Institute of Integrative Medicine, 759 Burwood Road, Hawthorn East, Melbourne, VIC 3123, Australia at this link: http://www.hindawi.com/journals/isrn/2012/575292/
Actually, the article is not a “paper on activity of 30c dilutions” as the title say. It is a work to show that potentized forms of ENANTIOMERS of drug molecules can work as SIMILIMUM. It discusses nothing about ‘what are the active principles of potentized drugs’, or ‘what is the biological mechanism by which potentized drugs act’.
“This paper reviews publications of laboratory experiments using pairs of enantiomers in homeopathy. Many molecules in nature have geometry which enables them to exist as nonsuperimposable mirror images or enantiomers. Modulation of toxicity of such molecules provides possibility for therapeutics, since they target multiple points in biochemical pathways. It was hypothesized that toxicity of a chemical agent could be counteracted by a homeopathic preparation of the enantiomer of the chemical agent.”
“A diverse body of data, including controlled laboratory studies, supports the conclusion that toxicity of optical isomers may be inhibited by homeopathic enantiomer preparations. These data were obtained with minimal or no pretesting to determine optimal test solutions. Inhibition of the excitotoxic neurotransmitter L-glutamic acid with homeopathic preparations of D-glutamic acid indicates the latter may be of use for amelioration of symptoms of disturbances of mood. Similarly, homeopathic preparation of (+)-nicotine may be of use for inhibition of effects of nicotine in tobacco.”
An ‘enantiomer ‘ is one of two stereoisomers that are mirror images of each other that are non-superimposable (not identical), much as one’s left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).
Organic compounds that contain a chiral carbon usually have two non-superimposable structures. These two structures are mirror images of each other and are, thus, commonly called enantiomers, hence this structural property is now commonly referred to as enantiomerism.
Enantiopure compounds refer to samples having, within the limits of detection, molecules of only one chirality.
Enantiomers have, when present in a symmetric environment, identical chemical and physical properties except for their ability to rotate plane-polarized light (+/−) by equal amounts but in opposite directions (although the polarized light can be considered an asymmetric medium). A mixture of equal parts of an optically active isomer and its enantiomer is termed racemic and has zero net rotation of plane-polarized light because the positive rotation of each (+) form is exactly counteracted by the negative rotation of a (−) one.
Enantiomers of each other often show different chemical reactions with other substances that are also enantiomers. Since many biological molecules are enantiomers themselves, there is sometimes a marked difference in the effects of two enantiomers on biological organisms. In drugs, for example, often only one of a drug’s enantiomers is responsible for the desired physiologic effects, while the other enantiomer is less active, inactive, or sometimes even responsible for adverse effects.
Enantiomers have similar FUNCTIONAL GROUPS, and hence they can act as homeopathic similimum. MIT has explained this phenomenon. See the links provided below.
Homeopathic potentization involves a process of ‘molecular imprinting’, where in the spacial conformation FUNCTIONAL GROUPS of individual drug molecules are ‘imprinted’ or engraved as hydrogen-bonded three dimensional nano-cavities into a supra-molecular matrix of water and ethyl alcohol, through a process of molecular level ‘host-guest’ interactions. These ‘molecular imprints’ or ‘hydrosomes’ are the active principles of post-avogadro dilutions used as homeopathic drugs
Potentized drugs contain molecular imprints of FUNCTIONAL GROUPS. Due to ‘conformational affinity’, molecular imprints can act as ‘artificial key holes’ or ‘ligand binds’ for the original drug molecules used for imprinting, and for all pathogenic molecules having functional groups ‘similar’ to those drug molecules. When used as therapeutic agents, molecular imprints selectively bind to the pathogenic molecules having conformational affinity and deactivate them, thereby relieving the biological molecules from the inhibitions or blocks caused by pathogenic molecules.
Molecular imprints of drug molecules can act as similimum if the drug molecules and pathogenic molecules have similar functional groups. The present observation by the researchers that enantiomers of chemical molecules having isomeric properties can act as similimum could be scientifically explained only on the basis of similar functional groups on enantiomers.
ACTUALLY, WHAT THIS STUDY EXACTLY PROVES IS THAT THE MIT OBSERVATION THAT ‘SIMILIMUM IS IS DECIDED BY SIMILARITY OF FUNCTIONAL GROUPS’ IS SCIENTIFICALLY VALIDATED.
This MIT concepts relating ‘similimum’ and ‘functional groups’ has been already explained in following articles written by me:
http://dialecticalhomeopathy.com/2013/11/24/potentized-drugs-are-functional-groups/
http://dialecticalhomeopathy.com/2011/12/14/similarity-of-functional-groups-of-drug-molecules-and-pathogenic-molecules-determines-similimum/
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