In my article HOW HOMEOPATHY WORKS, I have recorded as follows.
“Broadly speaking, the molecular errors which underlie diverse conditions of pathology belong to any of the following types:
1. Nutritional deficiencies of amino acids and other biological dtructural molecules: Any shortage in the availability of various amino acids and their precursers may lead to non- production of proteins in the organism. In some cases, it may result in the production of defective proteins.
2. The absence or defects of appropriate genetic materials, coding the information required for the production of various protein molecules utilizing amino acids, may inevitably lead to total failure of protein synthesis, or to production of defective proteins. These come under the class of genetic proteinopathies.
3. The deficiencies or errors related with the enzymes required for genetic expression in the process of protein synthesis and post-translational transitions may lead to non production of essential proteins, or may lead to production of defective proteins.
4. Any deficiencies( nutritional or metabolic)) or structural defects of co–factors and co-enzymes which help the protein molecules maintain their specific three-dimensional structure and activate them. This may be due to the nutritional deficiencies of essential elements and vitamins, or due to some errors in their metabolic pathways.
5. The absence of congenial physiologic conditions for protein molecules to remain active. Dehydrations, deviations of pH in the internal medium, variations of temperature, harmful radiations etc. may deactivate the protein molecules.
6. Absence or structural defects of certain substrate molecules (arising from nutritional deficiencies or metabolic causes) which are to interact with proteins in bio-chemic processes.
7. The inability of natural ligands to interact with legitimate target molecules due to inhibitions caused by binding of any foreign molecules or ions on ligands
8. Molecular inhibitions of target molecules, resulting from binding with exogenic or endogenic foreign molecules or ions, including metabolites, preventing natural ligands from binding to them
It is obvious that almost all conditions of pathology we normally confront, including those resulting from genetic origin, are involved with some or other errors or absence of some protein molecules that are essential for concerned bio-chemic processes. Moreover, most of such molecular errors other than of nutritional deficiencies or genetic origin, arise due to binding of some exogenic or endogenic foreign molecules or ions on the active, binding or allosteric sites of protein molecules, effecting changes in the three-dimensional configurations of protein molecules. A host of diseases originating from viral-bacterial infections, allergies, poisoning, drugs, food articles etc, belong to this category.
The most important factor we have to bear in mind when talking about kinetics of proteins in general, and enzymes in particular is their highly defined, peculiar specificity. Each type of protein molecules, or some times even some part of a single protein molecule, is designed in such a way that it can bind only with a specific class of molecules, and hence participate in a specific type of bio-chemic interaction only. This functional specificity is ensured through the peculiar three-dimensional configuration of the protein molecules, exhibited through their characteristic folding and spacial arrangement. Reactive chemical groups known as active sites, binding sites, and regulatory sites are distributed at specific locations on this three dimensional formations of protein molecules. These chemical groups can interact only with molecules and ions having appropriate spacial configurations that fits to their shape. This phenomenon can be compared with the relationship existing between a lock and its appropriate key. Just as a key with an exactly fitting three dimensional shape alone can enter the key hole of a lock and open it, molecules with exactly fitting three dimensional structure alone can establish contact and indulge in chemical activities with specific protein molecules. This key-lock relationship with substrates defines all biochemical interactions involving proteins, ensuring their optimum specificity. Obviously, any deviation in the three dimensional configuration of either lock or key makes their interaction impossible.
It has been already explained that the primary basis of any state of pathology is some deviations occurring in the biochemical processes at the molecular level. Endogenic or exogenic foreign molecules or ions having any configurational similarity to certain biochemical substrates can mimic as original substrates to attach themselves on the regulatory or the active sites of proteins, effecting changes in their native 3-D configuration, thereby making them unable to discharge their specific biochemical role. This situation is called a molecular inhibition, which leads to pathological molecular errors. It is comparable with the ability of objects having some similarity in shape with that of key, to enter the key hole of a lock and obstructing its function. As a result of this inhibition, the real substrates are prevented from interacting with the appropriate protein molecules, leading to a break in the normal biochemical channels. This type of molecular errors are called competitive inhibitions. It is in this way that many types of drugs, pesticides and poisons interfere in the biochemical processes, creating pathologic situations. Such substances are known as anti-melabolities.
Homeopathy has devised its own method of closely following even the minutest deviations in the biochemical processes in the organism, through a special strategy of monitoring and recording the perceivable symptoms caused by such deviations. Obviously, deviations in a particular biochemical pathway resulting from such a nano-level molecular inhibition produces a specific train of subjective and objective symptoms in the organism. In other words, each specific group of symptoms exhibited by the organism indicates a particular error occurred in the molecular level. Homoeopathy chases these train of symptoms to their minutest level, from periphery to interior, in order to study the exact molecular errors underlying any particular state of pathology. Not even the sophisticated tools of ultra-modern technologies can monitor those molecular errors with such perfection. Then, those pathological molecular inhibitions are removed by applying appropriate therapeutic agents, selected on the basis of ‘law of similars’ or ‘Similia Similibus Curentur’. This fundamental strategy underlying the homeopathic system of therapeutics evidently surpasses even the most scientific methods of modern molecular medicine. It is high time that the scientific world had realized and recognized this truth, and incorporated this wonderful tool into their armamentarium. Obviously, ‘similia similibus curentur’ is the most effective technique of identifying and removing the pathological molecular inhibitions in the organism.
’Secondary deficiencies’ can be treated by homeopathy. But it is not ‘malnutrition’, but faulty assimilation’. ‘Deficiency diseases’ and ‘malnutrition’ are different. All ‘deficiencies’ need not be ‘malnutrition’. With optimum nutrition, secondary deficiencies due to malabsorption or faulty assimilation could be treated by homeopathy.
Practically, it will be difficult to identify whether a particular case of ‘deficiency’ is due to deficient nutrition, faulty absorption or faulty assimilation and utilization. As such, in cases suspected to be related with deficiencies, I would propose a treatment plan consisting of ensuring well balanced diet and nutritional supplementation, along with administration of potentized drugs selected according to totality of symptoms.”
To maintain life, a living organism needs a regular supply of diverse types of molecules from the environment. Nutrition is the provision, to cells and organisms, of the materials necessary (in the form of food) to support life. Many common health problems originate from faulty nutrition.
A physician should be well aware of nutritional aspects of health, disease and cure. With advances in the fields of molecular biology, biochemistry, nutritional immunology, molecular medicine and genetics, the study of nutrition is increasingly concerned with metabolism and metabolic pathways: the sequences of biochemical steps through which substances in living things change from one form to another.
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